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North-West University National Metabolomics Platform

The National Metabolomics Platform (NMP) is the commercially driven Platform of the Centre for Human metabolomics and NWU, and it fulfils a niche in the South African Health sector by providing effective and efficient Metabolomic Analytic Services which is internationally competitive.

The NMP is aligning itself with International Standards ISO 17025 (General requirements for the competence of testing and calibration laboratories) and ISO 9000 (Quality management), ensuring the highest confidence in its results. To facilitate this process the NMP has set sail toward becoming a paperless institution through the acquisition of a Laboratory Information Management System (LIMS). The NMP LIMS system holds the capability of directly sending high priority electronic results straight to Health-Care Practitioners, putting our Doctors in a position to receive the much needed infrastructure for a speedy response.

The NMP is in collaboration with the oldest Biochemistry Laboratory in South Africa, Potchefstroom’s Laboratory for Inborn Errors of Metabolism (PLIEM), the New-born Screening (NBS) Laboratory as well as the Biotransformation and Oxidative Stress Laboratory (BOSS), working together to promote the South African economy and exploiting scientific technological advancements which will benefit all.

The NMP has the following technology available:

GCxGC-TOFMS
LC-IM-QTOFMS
NMR
LC-MS-MS

 

The NMP can perform the following services:

Targeted metabolomics Analysis:

* Amino acid analyses,
* Acylcarnitine analyses (acylglycines and acylglucuronides can be included for an additional cost),
* Organic acid analyses,
* Fatty acid methyl ester analyses (lipid bound fatty acid profiling),
* S-adenosylmethionine pathway analyses,
 

Untargeted metabolomics:

 

* LC-MS (liquid chromatography – mass spectrometry) analysis in positive and/or negative ionization mode is fit to screen metabolites belonging to the secondary metabolism,
* GC-MS (gas chromatography – mass spectrometry) analysis of silylated compounds covers mainly the metabolites belonging to the primary metabolism,
* H1-NMR (nuclear magnetic resonance) analysis is also fit for metabolites belonging to the primary metabolism that are in high concentrations.